![]() ![]() (2023), Corrigendum to "Impact of cancer-associated mutations in CC chemokine receptor 2 on receptor function and antagonism", Biochemical Pharmacology 209: 115540 (115450). van, Broekhuis J.D., Gorostiola Gonzalez M., Visser K.E. (2023), Gonadotrophin-releasing hormone receptors in GtoPdb v.2023.1, IUPHAR/BPS Guide to Pharmacology CITE 2023(1). Heitman L.H., IJzerman A.P., McArdle C.A.(2023), Kinetic profiling of novel spirobenzo-oxazinepiperidinone derivatives as equilibrative nucleoside transporter 1 inhibitors, Purinergic Signalling. de, Berthelot D., Pype S., Bosmans J.P., Vlijmen H. van der (2023), Development of an affinity-based probe to profile endogenous human adenosine A3 receptor expression, Journal of Medicinal Chemistry. Beerkens B.L.H., Snijders I.M., Snoeck J., Liu R., Tool A.T.J., Le Dévédec S.E., Jespers W., Kuijpers T.W., Westen G.J.P.I also served as chairman to FIGON, the Dutch federation for innovative drug research ( Contact I happily contribute to the IUPHAR adenosine receptor, GnRH, and nicotinic acid receptor nomenclature committees, and manage(d) quite a number of receptor-related research programs funded by Dutch scientific bodies such as the Top Institute Pharma, and by the European Union (most prominently and recently the 2012-2017 IMI consortium on drug target kinetics). My hope and dream is that once I will be able to show my students the wonder world of drug - receptor interactions through some sort of 'molecular microscope' Next to these teaching efforts other 'obligations' are the membership of the editorial boards of the Journal of Medicinal Chemistry, ChemMedChem, Purinergic Signalling, Chemistry & Biodiversity, Drug Development Research, Molecular Informatics, and Molecules. The art of medicinal chemistry", in which I explain and discus some principles and issues in medicinal chemistry If you're interested why not watch a weblecture called "Breaking and Making. You will find references to recent work at this website.ĭuties as a professor include teaching, which I like very much. All this has led to a scientific 'output' of over 260 articles, quite a few reviews and book chapters, a dozen or so patents, and some 20 accepted PhD theses. Every now and then I allow myself to diverge a little bit, lately to study nicotinic acid and chemokine CCR2 receptors. One cannot study all (800?) GPCRs at the time, so my main attention is focussed on adenosine receptors. In particular the molecular mechanisms of drug action are at the core of my research 'business'. My research interests have always been linked to G protein-coupled receptors (GPCRs). I was appointed assistant, associate and full professor of medicinal chemistry in Leiden in 1985, 19, respectively. Rather than opening a drug store I continued my research education, leading to the defense of my PhD thesis from the Vrije Universiteit in Amsterdam in 1985, on a subject in the area of receptor research. In 1979 I graduated with a specialization in pharmaceutical chemistry and one year later I qualified as a pharmacist. I studied pharmacy at Utrecht University. ![]()
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